Anti-DSG2 antibody (401-450 aa) (STJ92783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DSG2 at the amino acid range 401-450
General Information
| Short Description | Rabbit polyclonal anti-Desmoglein-2 (401-450 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DSG2 |
| Gene ID | 1829 |
| Uniprot ID | DSG2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DSG2 at the amino acid range 401-450 |
| Immunogen Region | 401-450 aa |
| Specificity | Dsg2 Polyclonal Antibody detects endogenous levels of Dsg2 protein. |
Additional Info
| Post Translational Modifications | Palmitoylated by ZDHHC5 at the plasma membrane. |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells. Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5. Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier. |
| Protein Name | Desmoglein-2Cadherin Family Member 5Hdgc |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeCytoplasm |
| Alternative Antibody Names | Anti-Desmoglein-2 antibodyAnti-Cadherin Family Member 5 antibodyAnti-Hdgc antibodyAnti-DSG2 antibodyAnti-CDHF5 antibody |
Information sourced from Uniprot.org