| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DSG1 |
| Gene ID: | 1828 |
| Uniprot ID: | DSG1_HUMAN |
| Immunogen Region: | 800-1049 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1049 of human DSG1 (NP_001933.2). |
| Immunogen Sequence: | SPHFGTTTVISESTYPSGPG VLHPKPILDPLGYGNVTVTE SYTTSDTLKPSVHVHDNRPA SNVVVTERVVGPISGADLHG MLEMPDLRDGSNVIVTERVI APSSSLPTSLTIHHPRESSN VVVTERVIQPTSGMIGSLSM HPELANAHNVIVTERVVSGA GVTGISGTTGISGGIGSSGL VGTSMGAGSGALSGAGISGG GIGLSSLGGTASIGHMRSSS DHHFNQTIGSASPSTARSR |
| Tissue Specificity | Epidermis, tongue, tonsil and esophagus. |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Protein Name | Desmoglein-1 Cadherin Family Member 4 Desmosomal Glycoprotein 1 Dg1 Dgi Pemphigus Foliaceus Antigen |
| Database Links | Reactome: R-HSA-351906 Reactome: R-HSA-6798695 Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Desmosome Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Desmoglein-1 antibody Anti-Cadherin Family Member 4 antibody Anti-Desmosomal Glycoprotein 1 antibody Anti-Dg1 antibody Anti-Dgi antibody Anti-Pemphigus Foliaceus Antigen antibody Anti-DSG1 antibody Anti-CDHF4 antibody |
Information sourced from Uniprot.org