Anti-DSCAM antibody (STJ192190)

SKU:
STJ192190

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cell adhesion molecule DSCAM is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DSCAM
Gene ID: 1826
Uniprot ID: DSCAM_HUMAN
Specificity: DSCAM Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Phosphorylated at tyrosine residues. Phosphorylation is enhanced by NTN1.
Function Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.
Protein Name Cell Adhesion Molecule Dscam
Chd2
Down Syndrome Cell Adhesion Molecule
Database Links Reactome: R-HSA-376172
Cellular Localisation Isoform Short: Secreted
Isoform Long: Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Dendrite
Growth Cone
Synapse
Localized In The Soma
Cell Membrane
Axon And Growth Cone Of Dissociated Commissural Axons
Alternative Antibody Names Anti-Cell Adhesion Molecule Dscam antibody
Anti-Chd2 antibody
Anti-Down Syndrome Cell Adhesion Molecule antibody
Anti-DSCAM antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance