• Western blot analysis of lysates from Rat testis, using Desmocollin 1 Rabbit monoclonal antibody (STJ11105164) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-DSC1 antibody (824-894) [S5164RM] (STJ11105164)

SKU:
STJ11105164

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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Desmocollin-1 (824-894) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S5164RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DSC1
Gene ID: 1823
Uniprot ID: DSC1_HUMAN
Immunogen Region: 824-894
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 824-894 of human Desmocollin 1 (NP_077739.1).
Immunogen Sequence: QPRLGEKVYLCGQDEEHKHC EDYVCSYNYEGKGSLAGSVG CCSDRQEEEGLEFLDHLEPK FRTLAKTCIKK
Tissue Specificity Strongly expressed in epidermis, less in lymph node and tongue.
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Protein Name Desmocollin-1
Cadherin Family Member 1
Desmosomal Glycoprotein 2/3
Dg2/Dg3
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Desmosome
Alternative Antibody Names Anti-Desmocollin-1 antibody
Anti-Cadherin Family Member 1 antibody
Anti-Desmosomal Glycoprotein 2/3 antibody
Anti-Dg2/Dg3 antibody
Anti-DSC1 antibody
Anti-CDHF1 antibody

Information sourced from Uniprot.org

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