| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DRG2 |
| Gene ID: | 1819 |
| Uniprot ID: | DRG2_HUMAN |
| Immunogen Region: | 150-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-260 of human DRG2 (NP_001379.1). |
| Immunogen Sequence: | TKGEVQRSLLEKELESVGIR LNKHKPNIYFKPKKGGGISF NSTVTLTQCSEKLVQLILHE YKIFNAEVLFREDCSPDEFI DVIVGNRVYMPCLYVYNKID QISMEEVDRLA |
| Tissue Specificity | Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes. |
| Post Translational Modifications | Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7.this modification hinders trypsin-catalyzed proteolysis in vitro. Polyubiquitinated. |
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. |
| Protein Name | Developmentally-Regulated Gtp-Binding Protein 2Drg-2Translation Factor Gtpase Drg2Trafac Gtpase Drg2 |
| Database Links | Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Developmentally-Regulated Gtp-Binding Protein 2 antibodyAnti-Drg-2 antibodyAnti-Translation Factor Gtpase Drg2 antibodyAnti-Trafac Gtpase Drg2 antibodyAnti-DRG2 antibody |
Information sourced from Uniprot.org