| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DRD3 |
| Gene ID: | 1814 |
| Uniprot ID: | DRD3_HUMAN |
| Immunogen Region: | 213-329 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 213-329 of human Dopamine Receptor D3 (Dopamine Receptor D3 (DRD3) ) (NP_000787.2). |
| Immunogen Sequence: | VVLKQRRRKRILTRQNSQCN SVRPGFPQQTLSPDPAHLEL KRYYSICQDTALGGPGFQER GGELKREEKTRNSLSPTIAP KLSLEVRKLSNGRLSTSLKL GPLQPRGVPLREKKATQ |
| Tissue Specificity | Brain. |
| Post Translational Modifications | Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). Palmitoylated. |
| Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. |
| Protein Name | D(3 Dopamine ReceptorDopamine D3 Receptor |
| Database Links | Reactome: R-HSA-390651Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBoth Membrane-Bound And Scattered In The Cytoplasm During Basal ConditionsReceptor Stimulation Results In The Rapid Internalization And Sequestration Of The Receptors At The Perinuclear Area (5 And 15 Minutes)Followed By The Dispersal Of The Receptors To The Membrane (30 Minutes)Drd3 And Grk4 Co-Localize In Lipid Rafts Of Renal Proximal Tubule Cells |
| Alternative Antibody Names | Anti-D(3 Dopamine Receptor antibodyAnti-Dopamine D3 Receptor antibodyAnti-DRD3 antibody |
Information sourced from Uniprot.org