| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DR6 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
TNFRSF21 |
| Gene ID: |
27242 |
| Uniprot ID: |
TNR21_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for DR6. |
| Immunogen: |
A synthetic peptide from c-terminal region of rat DR6 (Death receptor 6) conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 21Death Receptor 6Cd Antigen Cd358 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros) |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 21 antibodyAnti-Death Receptor 6 antibodyAnti-Cd Antigen Cd358 antibodyAnti-TNFRSF21 antibodyAnti-DR6 antibodyAnti-UNQ437 antibodyAnti-PRO868 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
