Anti-DPYSL2 antibody (C-Term) (STJA0005358)

SKU:
STJA0005358-100

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Host: Rabbit
Applications: WB/ICC/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CRMP2 (C-Term) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC 1:50
IP 1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DPYSL2
Gene ID: 1808
Uniprot ID: DPYL2_HUMAN
Immunogen Region: C-Term
Specificity: The antibody detects a 70 kDa* protein corresponding to the molecular mass of CRMP2 on SDS-PAGE immunoblots of human SKN-SH cells, mouse brain, and rat PC12 cells. This band on western blot can be specifically blocked using CRMP2 (C-terminal region)
Immunogen: CRMP2 synthetic peptide (coupled to carrier protein) corresponding to amino acids in the C-terminal region of human CRMP2. This sequence is conserved in rat and mouse CRMP2, and has high homology to the conserved site in CRMP1. It has 50% homology to
Tissue Specificity Ubiquitous.
Post Translational Modifications 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Protein Name Dihydropyrimidinase-Related Protein 2
Drp-2
Collapsin Response Mediator Protein 2
Crmp-2
N2a3
Unc-33-Like Phosphoprotein 2
Ulip-2
Database Links Reactome: R-HSA-399956
Reactome: R-HSA-437239
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Membrane
Tightly But Non-Covalently Associated With Membranes
Alternative Antibody Names Anti-Dihydropyrimidinase-Related Protein 2 antibody
Anti-Drp-2 antibody
Anti-Collapsin Response Mediator Protein 2 antibody
Anti-Crmp-2 antibody
Anti-N2a3 antibody
Anti-Unc-33-Like Phosphoprotein 2 antibody
Anti-Ulip-2 antibody
Anti-DPYSL2 antibody
Anti-CRMP2 antibody
Anti-ULIP2 antibody

Information sourced from Uniprot.org

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