Anti-DPY30 antibody (1-99) (STJ119825)

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STJ119825
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DPY30
Gene ID: 84661
Uniprot ID: DPY30_HUMAN
Immunogen Region: 1-99
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human DPY30 (NP_115963.1).
Immunogen Sequence: MEPEQMLEGQTQVAENPHSE YGLTDNVERIVENEKINAEK SSKQKVDLQSLPTRAYLDQT VVPILLQGLAVLAKERPPNP IEFLASYLLKNKAQFEDRN
Function As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
Protein Name Protein Dpy-30 Homolog
Dpy-30-Like Protein
Dpy-30l
Database Links Reactome: R-HSA-3214841
Reactome: R-HSA-5617472
Reactome: R-HSA-8936459
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Golgi Apparatus
Trans-Golgi Network
Associated With Chromatin At Regions Enriched In Histone H3 Trimethylated At 'Lys-4
Highly Enriched In Gene Promoter Regions And 5' Utrs
But Not In Downstream Regions Of Genes Or 3' Utrs
Alternative Antibody Names Anti-Protein Dpy-30 Homolog antibody
Anti-Dpy-30-Like Protein antibody
Anti-Dpy-30l antibody
Anti-DPY30 antibody

Information sourced from Uniprot.org

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