| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DPY30 (1-99) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DPY30 |
| Gene ID: |
84661 |
| Uniprot ID: |
DPY30_HUMAN |
| Immunogen Region: |
1-99 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-99 of human DPY30 (NP_115963.1). |
| Immunogen Sequence: |
MEPEQMLEGQTQVAENPHSE YGLTDNVERIVENEKINAEK SSKQKVDLQSLPTRAYLDQT VVPILLQGLAVLAKERPPNP IEFLASYLLKNKAQFEDRN |
| Function | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. |
| Protein Name | Protein Dpy-30 HomologDpy-30-Like ProteinDpy-30l |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusGolgi ApparatusTrans-Golgi NetworkAssociated With Chromatin At Regions Enriched In Histone H3 Trimethylated At 'Lys-4Highly Enriched In Gene Promoter Regions And 5' UtrsBut Not In Downstream Regions Of Genes Or 3' Utrs |
| Alternative Antibody Names | Anti-Protein Dpy-30 Homolog antibodyAnti-Dpy-30-Like Protein antibodyAnti-Dpy-30l antibodyAnti-DPY30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
