Anti-DPP8 antibody (10-230) (STJ29193)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DPP8 (10-230) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DPP8 |
| Gene ID | 54878 |
| Uniprot ID | DPP8_HUMAN |
| Immunogen Region | 10-230 |
| Immunogen Sequence | IKSGKCNMAAAMETEQLGVE IFETADCEENIESQDRPKLE PFYVERYSWSQLKKLLADTR KYHGYMMAKAPHDFMFVKRN DPDGPHSDRIYYLAMSGENR ENTLFYSEIPKTINRAAVLM LSWKPLLDLFQATLDYGMYS REEELLRERKRIGTVGIASY DYHQGSGTFLFQAGSGIYHV KDGGPQGFTQQPLRPNLVET SCPNIRMDPKLCPADPDWIA F |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 10-230 of human DPP8 (NP_932065.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 8Dp8Dipeptidyl Peptidase Iv-Related Protein 1Dprp-1Dipeptidyl Peptidase ViiiDpp ViiiProlyl Dipeptidase Dpp8 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dipeptidyl Peptidase 8 antibodyAnti-Dp8 antibodyAnti-Dipeptidyl Peptidase Iv-Related Protein 1 antibodyAnti-Dprp-1 antibodyAnti-Dipeptidyl Peptidase Viii antibodyAnti-Dpp Viii antibodyAnti-Prolyl Dipeptidase Dpp8 antibodyAnti-DPP8 antibodyAnti-DPRP1 antibodyAnti-MSTP097 antibodyAnti-MSTP135 antibodyAnti-MSTP141 antibody |
Information sourced from Uniprot.org