| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DPM1 |
| Gene ID: | 8813 |
| Uniprot ID: | DPM1_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1). |
| Immunogen Sequence: | MASLEVSRSPRRSRRELEVR SPRQNKYSVLLPTYNERENL PLIVWLLVKSFSESGINYEI IIIDDGSPDGTRDVAEQLEK IYGSDRILLRPREKKLGLGT AYIHGMKHATGNYIIIMDAD LSHHPKFIPEFIRKQKEGNF DIVSGTRYKGNGGVYGWDLK RKIISRGANFLTQILLRPGA SDLTGSFRLYRKEVLEKLIE KCVSKGYVFQMEMIVRARQL NYTIGEVPISFVDRVYGES |
| Function | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. |
| Protein Name | Dolichol-Phosphate Mannosyltransferase Subunit 1Dolichol-Phosphate Mannose Synthase Subunit 1Dpm Synthase Subunit 1Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 1Mannose-P-Dolichol Synthase Subunit 1Mpd Synthase Subunit 1 |
| Database Links | Reactome: R-HSA-162699Reactome: R-HSA-4717374Reactome: R-HSA-4719360Reactome: R-HSA-4719377 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Dolichol-Phosphate Mannosyltransferase Subunit 1 antibodyAnti-Dolichol-Phosphate Mannose Synthase Subunit 1 antibodyAnti-Dpm Synthase Subunit 1 antibodyAnti-Dolichyl-Phosphate Beta-D-Mannosyltransferase Subunit 1 antibodyAnti-Mannose-P-Dolichol Synthase Subunit 1 antibodyAnti-Mpd Synthase Subunit 1 antibodyAnti-DPM1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89724/358205/STJ11100788_1__51624.1713122526.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
