| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
DPH1 |
| Gene ID: |
1801 |
| Uniprot ID: |
DPH1_HUMAN |
| Immunogen Region: |
190-290 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 190-290 of human DPH1 (NP_001374.3). |
| Immunogen Sequence: |
LQAAAQELKAEYRVSVPQCK PLSPGEILGCTSPRLSKEVE AVVYLGDGRFHLESVMIANP NVPAYRYDPYSKVLSREHYD HQRMQAARQEAIATARSAKS W |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. |
| Function | Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as a tumor suppressor. |
| Protein Name | 2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 1Diphthamide Biosynthesis Protein 1Diphtheria Toxin Resistance Protein 1Ovarian Cancer-Associated Gene 1 ProteinS-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 1 |
| Database Links | Reactome: R-HSA-5358493 |
| Cellular Localisation | NucleusCytoplasmPunctatePrimarily Perinuclear Localization |
| Alternative Antibody Names | Anti-2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 1 antibodyAnti-Diphthamide Biosynthesis Protein 1 antibodyAnti-Diphtheria Toxin Resistance Protein 1 antibodyAnti-Ovarian Cancer-Associated Gene 1 Protein antibodyAnti-S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 1 antibodyAnti-DPH1 antibodyAnti-DPH2L antibodyAnti-DPH2L1 antibodyAnti-OVCA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
