| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. |
| Function | Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as a tumor suppressor. |
| Protein Name | 2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 1Diphthamide Biosynthesis Protein 1Diphtheria Toxin Resistance Protein 1Ovarian Cancer-Associated Gene 1 ProteinS-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 1 |
| Database Links | Reactome: R-HSA-5358493 |
| Cellular Localisation | NucleusCytoplasmPunctatePrimarily Perinuclear Localization |
| Alternative Antibody Names | Anti-2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 1 antibodyAnti-Diphthamide Biosynthesis Protein 1 antibodyAnti-Diphtheria Toxin Resistance Protein 1 antibodyAnti-Ovarian Cancer-Associated Gene 1 Protein antibodyAnti-S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 1 antibodyAnti-DPH1 antibodyAnti-DPH2L antibodyAnti-DPH2L1 antibodyAnti-OVCA1 antibody |
Information sourced from Uniprot.org
