| Tissue Specificity | Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level). |
| Function | Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling. |
| Protein Name | Sodium-Dependent Dopamine TransporterDa TransporterDatSolute Carrier Family 6 Member 3 |
| Database Links | Reactome: R-HSA-379401Reactome: R-HSA-442660Reactome: R-HSA-5619081Reactome: R-HSA-5660724 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neurite Tips In Neuronal CellsColocalizes With Septin4 At Axon TerminalsEspecially At The Varicosities |
| Alternative Antibody Names | Anti-Sodium-Dependent Dopamine Transporter antibodyAnti-Da Transporter antibodyAnti-Dat antibodyAnti-Solute Carrier Family 6 Member 3 antibodyAnti-SLC6A3 antibodyAnti-DAT1 antibody |
Information sourced from Uniprot.org
