• GIST stained with DOG-1 antibody using peroxidase-conjugate and DAB chromogen. Note the strong cytoplasmic staining of tumor cells.

Anti-DOG1 antibody [DOG1.1] (STJ180085)

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STJ180085

£152.50 - £544.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-DOG1 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: DOG1.1
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: ANO1
Gene ID: 55107
Uniprot ID: ANO1_HUMAN
Specificity: Positive control: Breast carcinomas
Immunogen: Synthetic peptides FLJ34272 specific to human gastrointestinal stromal tumor (GIST)
Tissue Specificity Expressed in nasal epithelial cells (at protein level). In the kidney, expressed in the collecting duct (at protein level). Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles. Expressed in eccrine sweat glands.
Function Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment. Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC. However, was shown in another study not to be required for MUC5AC expression. Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset. In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity. Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae. Acts as a heat sensor in nociceptive neurons. In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs. In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells. Isoform 4: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. Isoform 5: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+).
Protein Name Anoctamin-1
Discovered On Gastrointestinal Stromal Tumors Protein 1
Oral Cancer Overexpressed Protein 2
Transmembrane Protein 16a
Tumor-Amplified And Overexpressed Sequence 2
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9733458
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Presynapse
In Differentiating Airway Epithelial Cells
Predominantly Intracellular At Day 0 But Is Apically Localized By Day 30
Expressed In The Presynapse Of Retinal Neurons
Alternative Antibody Names Anti-Anoctamin-1 antibody
Anti-Discovered On Gastrointestinal Stromal Tumors Protein 1 antibody
Anti-Oral Cancer Overexpressed Protein 2 antibody
Anti-Transmembrane Protein 16a antibody
Anti-Tumor-Amplified And Overexpressed Sequence 2 antibody
Anti-ANO1 antibody
Anti-DOG1 antibody
Anti-ORAOV2 antibody
Anti-TAOS2 antibody
Anti-TMEM16A antibody

Information sourced from Uniprot.org

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