| Tissue Specificity | Expressed in peripheral blood mononuclear cells (PBMCs). |
| Post Translational Modifications | In response to chemokine CXCL12/SDF-1-alpha stimulation, phosphorylated by PRKCA/PKC-alpha which promotes DOCK8 dissociation from LRCH1. |
| Function | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. |
| Protein Name | Dedicator Of Cytokinesis Protein 8 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013409Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneEnriched And Co-Localizes With Gtpase Cdc42 At The Immunological Synapse Formed During T Cell/Antigen Presenting Cell Cognate InteractionTranslocates From The Cytoplasm To The Plasma Membrane In Response To Chemokine Cxcl12/Sdf-1-Alpha Stimulation |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 8 antibodyAnti-DOCK8 antibody |
Information sourced from Uniprot.org
