| Function | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation.negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. |
| Protein Name | Dedicator Of Cytokinesis Protein 7 |
| Database Links | Reactome: R-HSA-8875555Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-983231 |
| Cellular Localisation | Cell ProjectionAxonEnriched In The Developing Axons Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 7 antibodyAnti-DOCK7 antibodyAnti-KIAA1771 antibody |
Information sourced from Uniprot.org
