| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Dedicator of cytokinesis protein 10 (2051-2101 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOCK10 |
| Gene ID: | 55619 |
| Uniprot ID: | DOC10_HUMAN |
| Immunogen Region: | 2051-2101 aa |
| Specificity: | This antibody detects endogenous levels of DOC10 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human DOC10 at the amino acid range 2051-2101 |
| Function | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. |
| Protein Name | Dedicator Of Cytokinesis Protein 10Zizimin-3 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionDendritic Spine |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 10 antibodyAnti-Zizimin-3 antibodyAnti-DOCK10 antibodyAnti-KIAA0694 antibodyAnti-ZIZ3 antibody |
Information sourced from Uniprot.org
