Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Double C2-like domain-containing protein beta (332-382 aa) is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DOC2B |
Gene ID: | 8447 |
Uniprot ID: | DOC2B_HUMAN |
Immunogen Region: | 332-382 aa |
Specificity: | This antibody detects endogenous levels of DOC2B at Human/Mouse/Rat |
Immunogen: | Synthesized peptide derived from the human DOC2B at the amino acid range 332-382 |
Function | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. |
Protein Name | Double C2-Like Domain-Containing Protein Beta Doc2-Beta |
Cellular Localisation | Cytoplasm Cytoplasmic Granule Cell Membrane Peripheral Membrane Protein Translocates To The Plasma Membrane In A Calcium-Dependent Manner |
Alternative Antibody Names | Anti-Double C2-Like Domain-Containing Protein Beta antibody Anti-Doc2-Beta antibody Anti-DOC2B antibody Anti-DOC2BL antibody |
Information sourced from Uniprot.org