| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dnmt3b (50-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 Mu g/Mu l |
| Dilution Range: |
ELISA 1:10, 000ICC 1:50-1:100IF 1:50-1:100IHC 1:50-1:100IP 1:200WB 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Dnmt3b |
| Gene ID: |
13436 |
| Uniprot ID: |
DNM3B_MOUSE |
| Immunogen Region: |
50-100 |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 50-100 on mouse DNA (cytosine-5)-methyltransferase 3B protein. |
| Function | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells. |
| Protein Name | DnaCytosine-5-Methyltransferase 3bDnmt3bDna Methyltransferase MmuiiibDna Mtase MmuiiibM.mmuiiib |
| Database Links | Reactome: R-MMU-212300Reactome: -MMU-4655427 |
| Cellular Localisation | NucleusAccumulates In The Major Satellite Repeats At Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Dna antibodyAnti-Cytosine-5-Methyltransferase 3b antibodyAnti-Dnmt3b antibodyAnti-Dna Methyltransferase Mmuiiib antibodyAnti-Dna Mtase Mmuiiib antibodyAnti-M.mmuiiib antibodyAnti-Dnmt3b antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
