| Host: |
Mouse |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Dynamin-2 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
5E4C2F3 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNM2 |
| Gene ID: |
1785 |
| Uniprot ID: |
DYN2_HUMAN |
| Specificity: |
Dynamin II Monoclonal Antibody detects endogenous levels of Dynamin II protein. |
| Immunogen: |
Purified recombinant fragment of Dynamin II expressed in E. Coli. |
| Post Translational Modifications | Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2. Phosphorylated on tyrosine residues after activation of SRC. |
| Function | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. |
| Protein Name | Dynamin-2 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-177504Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-203641Reactome: R-HSA-2132295Reactome: R-HSA-432720Reactome: R-HSA-432722Reactome: R-HSA-437239Reactome: R-HSA-8856828Reactome: R-HSA-9031628 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionMembraneClathrin-Coated PitPostsynaptic DensitySynapseMidbodyCell ProjectionPhagocytic CupCytoplasmic VesiclePhagosome MembranePeripheral Membrane ProteinColocalizes With Cttn At The Basis Of Filopodia In Hippocampus Neuron Growth ZonesMicrotubule-AssociatedAlso Found In The Postsynaptic Density Of Neuronal CellsCo-Localizes With Pik3c3 And Rab5a To The Nascent Phagosome |
| Alternative Antibody Names | Anti-Dynamin-2 antibodyAnti-DNM2 antibodyAnti-DYN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
