| Post Translational Modifications | Phosphorylation at Ser-774 by GSK3B/GSK3-beta leads to inactivation of receptor-mediated endocytosis in non-neuronal cells. Dephosphorylation at Ser-774, through the EGFR downstream signaling, leads to activation and regulates early stages of clathrin-mediated endocytosis (CME). Phosphorylated by CDK5 leading to synaptic vesicle endocytosis (SVE) activation. |
| Function | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks. Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis. Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission. May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR. Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses. Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity. Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells. Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation. |
| Protein Name | Dynamin-1DynaminDynamin I |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-177504Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-2132295Reactome: R-HSA-3928665Reactome: R-HSA-437239Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMembraneClathrin-Coated PitCytoplasmic VesiclePresynapseSecretory VesicleChromaffin GranuleAssociated To The Membrane In A Helical Polymer Shape In A Gtp Bound StateTransiently Recruited To Endocytic Clathrin-Coated Pits (Ccps) At A Late Stage Of Clathrin-Coated Vesicle (Ccv) Formation |
| Alternative Antibody Names | Anti-Dynamin-1 antibodyAnti-Dynamin antibodyAnti-Dynamin I antibodyAnti-DNM1 antibodyAnti-DNM antibody |
Information sourced from Uniprot.org
