| Function | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| Protein Name | Dnaj Homolog Subfamily C Member 3Endoplasmic Reticulum Dna J Domain-Containing Protein 6Er-Resident Protein Erdj6Erdj6Interferon-Induced - Double-Stranded Rna-Activated Protein Kinase InhibitorProtein Kinase Inhibitor Of 58 KdaProtein Kinase Inhibitor P58 |
| Database Links | Reactome: R-HSA-192823Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-6798695Reactome: R-HSA-8957275Reactome: R-HSA-9833482 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 3 antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 6 antibodyAnti-Er-Resident Protein Erdj6 antibodyAnti-Erdj6 antibodyAnti-Interferon-Induced - Double-Stranded Rna-Activated Protein Kinase Inhibitor antibodyAnti-Protein Kinase Inhibitor Of 58 Kda antibodyAnti-Protein Kinase Inhibitor P58 antibodyAnti-DNAJC3 antibodyAnti-P58IPK antibodyAnti-PRKRI antibody |
Information sourced from Uniprot.org
