Anti-DNAJB9 antibody (61-75) (STJ72616)

SKU:
STJ72616-100
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Host: Goat
Applications: Pep-ELISA/WB/IF/FC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-DNAJB9 (61-75) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:16000.
WB: Approx 26-27kDa band observed in Human Liver and Kidney lysates and approx.28kDa in Mouse Liver lysates and in preliminary testing of Rat Liver lysate (calculated MW of 25.5kDa accordi
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: DNAJB9
Gene ID: 4189
Uniprot ID: DNJB9_HUMAN
Immunogen Region: 61-75
Accession Number: NP_036460.1
Immunogen Sequence: PDAEAKFREIAEAYE
Function Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.
Protein Name Dnaj Homolog Subfamily B Member 9
Endoplasmic Reticulum Dna J Domain-Containing Protein 4
Er-Resident Protein Erdj4
Erdj4
Microvascular Endothelial Differentiation Gene 1 Protein
Mdg-1
Database Links Reactome: R-HSA-381038
Cellular Localisation Endoplasmic Reticulum Lumen
Alternative Antibody Names Anti-Dnaj Homolog Subfamily B Member 9 antibody
Anti-Endoplasmic Reticulum Dna J Domain-Containing Protein 4 antibody
Anti-Er-Resident Protein Erdj4 antibody
Anti-Erdj4 antibody
Anti-Microvascular Endothelial Differentiation Gene 1 Protein antibody
Anti-Mdg-1 antibody
Anti-DNAJB9 antibody
Anti-MDG1 antibody
Anti-UNQ743 antibody
Anti-PRO1471 antibody

Information sourced from Uniprot.org