| Host: | Rabbit |
| Applications: | WB/IHC-P |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-DNAJB6 (162-175 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | R01-8K2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/ml |
| Dilution Range: | WB 1:500-1:1000 IHC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | DNAJB6 |
| Gene ID: | 10049 |
| Uniprot ID: | DNJB6_HUMAN |
| Immunogen Region: | 162-175 aa |
| Immunogen: | Recombinant protein of human DNAJB6 |
| Tissue Specificity | Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. |
| Function | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity. Isoform B: Isoform B but not isoform A inhibits huntingtin aggregation. |
| Protein Name | Dnaj Homolog Subfamily B Member 6 Hhdj1 Heat Shock Protein J2 Hsj-2 Mrj Msj-1 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm Perinuclear Region Nucleus Myofibril Sarcomere Z Line |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 6 antibody Anti-Hhdj1 antibody Anti-Heat Shock Protein J2 antibody Anti-Hsj-2 antibody Anti-Mrj antibody Anti-Msj-1 antibody Anti-DNAJB6 antibody Anti-HSJ2 antibody Anti-MRJ antibody Anti-MSJ1 antibody |
Information sourced from Uniprot.org