| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Disks large homolog 5 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DLG5 |
| Gene ID: |
9231 |
| Uniprot ID: |
DLG5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DLG5 at Human |
| Immunogen: |
Synthesized peptide derived from human DLG5 |
| Function | Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons.regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. |
| Protein Name | Disks Large Homolog 5Discs Large Protein P-DlgPlacenta And Prostate Dlg |
| Database Links | Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell JunctionCell MembranePeripheral Membrane ProteinPostsynaptic DensityCytoplasmCytoskeletonCilium Basal BodyLocalized At Sites Of Cell-Cell Contact |
| Alternative Antibody Names | Anti-Disks Large Homolog 5 antibodyAnti-Discs Large Protein P-Dlg antibodyAnti-Placenta And Prostate Dlg antibodyAnti-DLG5 antibodyAnti-KIAA0583 antibodyAnti-PDLG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
