| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Disks large homolog 1 (70-120 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DLG1 |
| Gene ID: |
1739 |
| Uniprot ID: |
DLG1_HUMAN |
| Immunogen Region: |
70-120 aa |
| Specificity: |
DLG1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein at the amino acid range 70-120 |
| Post Translational Modifications | Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Ubiquitinated.by MARCHF2 which results in its degradation. |
| Function | Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane. |
| Protein Name | Disks Large Homolog 1Synapse-Associated Protein 97Sap-97Sap97Hdlg |
| Database Links | Reactome: R-HSA-399719Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-447038Reactome: R-HSA-451308Reactome: R-HSA-5673001Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | MembranePeripheral Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembranePostsynaptic DensitySynapseCell MembraneSarcolemmaApical Cell MembraneCell JunctionCytoplasmColocalizes With Epb41 At Regions Of Intercellular ContactsBasolateral In Epithelial CellsMay Also Associate With Endoplasmic Reticulum MembranesMainly Found In Neurons SomaModerately Found At Postsynaptic Densities |
| Alternative Antibody Names | Anti-Disks Large Homolog 1 antibodyAnti-Synapse-Associated Protein 97 antibodyAnti-Sap-97 antibodyAnti-Sap97 antibodyAnti-Hdlg antibodyAnti-DLG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
