Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S5MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DKK3 |
Gene ID: | 27122 |
Uniprot ID: | DKK3_HUMAN |
Immunogen Region: | 200-350 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-350 of human DKK3 (Q9UBP4) (NP_056965.3) |
Immunogen Sequence: | TRGSNGTICDNQRDCQPGLC CAFQRGLLFPVCTPLPVEGE LCHDPASRLLDLITWELEPD GALDRCPCASGLLCQPHSHS LVYVCKPTFVGSRDQDGEIL LPREVPDEYEVGSFMEEVRQ ELEDLERSLTEEMALREPAA AAAALLGGEEI |
Tissue Specificity | Highest expression in heart, brain, and spinal cord. |
Post Translational Modifications | N- and O-glycosylated. |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Protein Name | Dickkopf-Related Protein 3Dickkopf-3Dkk-3Hdkk-3 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Dickkopf-Related Protein 3 antibodyAnti-Dickkopf-3 antibodyAnti-Dkk-3 antibodyAnti-Hdkk-3 antibodyAnti-DKK3 antibodyAnti-REIC antibodyAnti-UNQ258 antibodyAnti-PRO295 antibody |
Information sourced from Uniprot.org