Anti-DKK1 nanobody [SAA1268] (STJN000062)

Anti-DKK1 nanobody [SAA1268] (STJN000062)

SKU:
STJN000062
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Short Description :Alpaca monoclonal nanobody anti-Dickkopf-Related Protein 1 is suitable for use in ELISA research applications.
Applications:ELISA
Host:Alpaca
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SAA1268
Isotype:VHH-8His-Cys-tag
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by Nickel column.
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol:DKK1
Gene ID:22943
Uniprot ID:DKK1_HUMAN
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name Dickkopf-Related Protein 1
Dickkopf-1
Dkk-1
Hdkk-1
Sk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Nanobody Names Anti-Dickkopf-Related Protein 1 nanobody
Anti-Dickkopf-1 nanobody
Anti-Dkk-1 nanobody
Anti-Hdkk-1 nanobody
Anti-Sk nanobody
Anti-DKK1 nanobody
Anti-UNQ492 nanobody
Anti-PRO1008 nanobody

Information sourced from Uniprot.org

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