Anti-DKK1 antibody [SAA2072] (STJA0021857)

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STJA0021857
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: ELISA/Neut
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Dickkopf-Related Protein 1 is suitable for use in ELISA and Universal research applications.
Clonality : Monoclonal
Clone ID : SAA2072
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: DKK1
Gene ID: 22943
Uniprot ID: DKK1_HUMAN
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
Protein Name Dickkopf-Related Protein 1
Dickkopf-1
Dkk-1
Hdkk-1
Sk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Antibody Names Anti-Dickkopf-Related Protein 1 antibody
Anti-Dickkopf-1 antibody
Anti-Dkk-1 antibody
Anti-Hdkk-1 antibody
Anti-Sk antibody
Anti-DKK1 antibody
Anti-UNQ492 antibody
Anti-PRO1008 antibody

Information sourced from Uniprot.org

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