Anti-DKK1 antibody (32-266) (STJ23386)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DKK1 (32-266) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DKK1 |
| Gene ID | 22943 |
| Uniprot ID | DKK1_HUMAN |
| Immunogen Region | 32-266 |
| Immunogen Sequence | TLNSVLNSNAIKNLPPPLGG AAGHPGSAVSAAPGILYPGG NKYQTIDNYQPYPCAEDEEC GTDEYCASPTRGGDAGVQIC LACRKRRKRCMRHAMCCPGN YCKNGICVSSDQNHFRGEIE ETITESFGNDHSTLDGYSRR TTLSSKMYHTKGQEGSVCLR SSDCASGLCCARHFWSKICK PVLKEGQVCTKHRRKGSHGL EIFQRCYCGEGLSCRIQKDH HQASNSSRLHTCQRH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 32-266 of human DKK1 (NP_036374.1). |
Additional Info
| Tissue Specificity | Placenta. |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. |
| Protein Name | Dickkopf-Related Protein 1Dickkopf-1Dkk-1Hdkk-1Sk |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dickkopf-Related Protein 1 antibodyAnti-Dickkopf-1 antibodyAnti-Dkk-1 antibodyAnti-Hdkk-1 antibodyAnti-Sk antibodyAnti-DKK1 antibodyAnti-UNQ492 antibodyAnti-PRO1008 antibody |
Information sourced from Uniprot.org