| Tissue Specificity | Widely expressed. Highly expressed in the pancreas. |
| Function | Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal.polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy. |
| Protein Name | Polyprenol DehydrogenaseDhrsxyDehydrogenase/Reductase Sdr Family Member On Chromosome XDolichal Reductase |
| Cellular Localisation | Lipid DropletSecretedSecreted In A Non-Classical FormA Signal Peptide Sequence At Position 1-31 Is Predicted |
| Alternative Antibody Names | Anti-Polyprenol Dehydrogenase antibodyAnti-Dhrsxy antibodyAnti-Dehydrogenase/Reductase Sdr Family Member On Chromosome X antibodyAnti-Dolichal Reductase antibodyAnti-DHRSX antibodyAnti-CXorf11 antibodyAnti-DHRS5X antibodyAnti-SDR46C1 antibodyAnti-SDR7C6 antibodyAnti-UNQ6508 antibodyAnti-PRO21433 antibody |
Information sourced from Uniprot.org
