Anti-DHRS4 antibody (1-278) (STJ112323)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DHRS4 (1-278) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHRS4 |
| Gene ID | 10901 |
| Uniprot ID | DHRS4_HUMAN |
| Immunogen Region | 1-278 |
| Immunogen Sequence | MHKAGLLGLCARAWNSVRMA SSGMTRRDPLANKVALVTAS TDGIGFAIARRLAQDGAHVV VSSRKQQNVDQAVATLQGEG LSVTGTVCHVGKAEDRERLV ATAVKLHGGIDILVSNAAVN PFFGSIMDVTEEVWDKTLDI NVKAPALMTKAVVPEMEKRG GGSVVIVSSIAAFSPSPGFS PYNVSKTALLGLTKTLAIEL APRNIRVNCLAPGLIKTSFS RMLWMDKEKEESMKETLRI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human DHRS4 (NP_066284.2). |
Additional Info
| Tissue Specificity | Isoform 1: Predominantly expressed in normal cervix (at protein level). Isoform 4: Expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5: Expressed in a few neoplastic cervical tissues. Isoform 6: Expressed in a few neoplastic cervical tissues. Isoform 8: High expression in liver. |
| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin. Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals. In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Isoform 7: No detected catalytic activity in vitro, possibly due to the lack of catalytic site. Isoform 8: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 4Nadph-Dependent Carbonyl ReductaseCrNadph-Dependent Retinol Dehydrogenase/ReductaseNrdrHumnrdrPeroxisomal Short-Chain Alcohol DehydrogenasePscdScad-SrlShort Chain Dehydrogenase/Reductase Family 25c Member 2Protein Sdr25c2Short-Chain Dehydrogenase/Reductase Family Member 4 |
| Database Links | Reactome: R-HSA-5365859Reactome: R-HSA-9033241 |
| Cellular Localisation | Isoform 1: PeroxisomeIsoform 4 Is Not PeroxisomalIsoform 7: Nucleus |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 4 antibodyAnti-Nadph-Dependent Carbonyl Reductase antibodyAnti-Cr antibodyAnti-Nadph-Dependent Retinol Dehydrogenase/Reductase antibodyAnti-Nrdr antibodyAnti-Humnrdr antibodyAnti-Peroxisomal Short-Chain Alcohol Dehydrogenase antibodyAnti-Pscd antibodyAnti-Scad-Srl antibodyAnti-Short Chain Dehydrogenase/Reductase Family 25c Member 2 antibodyAnti-Protein Sdr25c2 antibodyAnti-Short-Chain Dehydrogenase/Reductase Family Member 4 antibodyAnti-DHRS4 antibodyAnti-SDR25C2 antibodyAnti-UNQ851 antibodyAnti-PRO1800 antibody |
Information sourced from Uniprot.org