Anti-DHRS11 antibody (1-260) (STJ116807)

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STJ116807
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DHRS11
Gene ID: 79154
Uniprot ID: DHR11_HUMAN
Immunogen Region: 1-260
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DHRS11 (NP_077284.2).
Immunogen Sequence: MARPGMERWRDRLALVTGAS GGIGAAVARALVQQGLKVVG CARTVGNIEELAAECKSAGY PGTLIPYRCDLSNEEDILSM FSAIRSQHSGVDICINNAGL ARPDTLLSGSTSGWKDMFNV NVLALSICTREAYQSMKERN VDDGHIININSMSGHRVLPL SVTHFYSATKYAVTALTEGL RQELREAQTHIRATCISPGV VETQFAFKLHDKDPEKAAAT YEQMKCLKPEDVAEAVIYV
Tissue Specificity Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle.
Function Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Protein Name Dehydrogenase/Reductase Sdr Family Member 11
17-Beta-Hydroxysteroid Dehydrogenase
3-Beta-Hydroxysteroid 3-Dehydrogenase
Estradiol 17-Beta-Dehydrogenase
Short-Chain Dehydrogenase/Reductase Family 24c Member 1
Cellular Localisation Secreted
Alternative Antibody Names Anti-Dehydrogenase/Reductase Sdr Family Member 11 antibody
Anti-17-Beta-Hydroxysteroid Dehydrogenase antibody
Anti-3-Beta-Hydroxysteroid 3-Dehydrogenase antibody
Anti-Estradiol 17-Beta-Dehydrogenase antibody
Anti-Short-Chain Dehydrogenase/Reductase Family 24c Member 1 antibody
Anti-DHRS11 antibody
Anti-SDR24C1 antibody
Anti-UNQ836 antibody
Anti-PRO1774 antibody

Information sourced from Uniprot.org

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