| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DHRS11 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHRS11 |
| Gene ID: |
79154 |
| Uniprot ID: |
DHR11_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DHRS11 (NP_077284.2). |
| Immunogen Sequence: |
MARPGMERWRDRLALVTGAS GGIGAAVARALVQQGLKVVG CARTVGNIEELAAECKSAGY PGTLIPYRCDLSNEEDILSM FSAIRSQHSGVDICINNAGL ARPDTLLSGSTSGWKDMFNV NVLALSICTREAYQSMKERN VDDGHIININSMSGHRVLPL SVTHFYSATKYAVTALTEGL RQELREAQTHIRATCISPGV VETQFAFKLHDKDPEKAAAT YEQMKCLKPEDVAEAVIYV |
| Tissue Specificity | Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart. Isoform 3: Expressed in brain, heart and skeletal muscle. |
| Function | Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 1117-Beta-Hydroxysteroid Dehydrogenase3-Beta-Hydroxysteroid 3-DehydrogenaseEstradiol 17-Beta-DehydrogenaseShort-Chain Dehydrogenase/Reductase Family 24c Member 1 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 11 antibodyAnti-17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-3-Beta-Hydroxysteroid 3-Dehydrogenase antibodyAnti-Estradiol 17-Beta-Dehydrogenase antibodyAnti-Short-Chain Dehydrogenase/Reductase Family 24c Member 1 antibodyAnti-DHRS11 antibodyAnti-SDR24C1 antibodyAnti-UNQ836 antibodyAnti-PRO1774 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89724/358205/STJ11100788_1__51624.1713122526.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and APEH knockout (KO) 293T cells, using [KO Validated] APEH Rabbit polyclonal antibody (STJ11100788) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")