| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DHFR |
| Gene ID: | 1719 |
| Uniprot ID: | DYR_HUMAN |
| Immunogen Region: | 88-187 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 88-187 of human DHFR (NP_000782.1). |
| Immunogen Sequence: | HFLSRSLDDALKLTEQPELA NKVDMVWIVGGSSVYKEAMN HPGHLKLFVTRIMQDFESDT FFPEIDLEKYKLLPEYPGVL SDVQEEKGIKYKFEVYEKND |
| Tissue Specificity | Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. |
| Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. |
| Protein Name | Dihydrofolate Reductase |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-196757Reactome: R-HSA-69205 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Dihydrofolate Reductase antibodyAnti-DHFR antibody |
Information sourced from Uniprot.org