| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DHDDS (20-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHDDS |
| Gene ID: |
79947 |
| Uniprot ID: |
DHDDS_HUMAN |
| Immunogen Region: |
20-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human DHDDS (NP_995583.1). |
| Immunogen Sequence: |
IKAGPMPKHIAFIMDGNRRY AKKCQVERQEGHSQGFNKLA ETLRWCLNLGILEVTVYAFS IENFKRSKSEVDGLMDLARQ KFSRLMEEKEKLQKHGVCIR VLGDLHLLPLDLQELIAQAV QATKNYNKCFLNVCFAYTSR HEISNAVREMAWGVEQGLLD PSDISESLLDKCLYTNRSPH P |
| Tissue Specificity | Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. |
| Function | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit DhddsCis-IsoprenyltransferaseCitCis-IptaseCis-Prenyltransferase Subunit HcitEpididymis Tissue Protein Li 189m |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinColocalizes With Calnexin |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds antibodyAnti-Cis-Isoprenyltransferase antibodyAnti-Cit antibodyAnti-Cis-Iptase antibodyAnti-Cis-Prenyltransferase Subunit Hcit antibodyAnti-Epididymis Tissue Protein Li 189m antibodyAnti-DHDDS antibodyAnti-HDS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
