| Tissue Specificity | Ubiquitous. Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). |
| Function | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. |
| Protein Name | Dehydrodolichyl Diphosphate Synthase Complex Subunit DhddsCis-IsoprenyltransferaseCitCis-IptaseCis-Prenyltransferase Subunit HcitEpididymis Tissue Protein Li 189m |
| Database Links | Reactome: R-HSA-446199Reactome: R-HSA-4755609 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinColocalizes With Calnexin |
| Alternative Antibody Names | Anti-Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds antibodyAnti-Cis-Isoprenyltransferase antibodyAnti-Cit antibodyAnti-Cis-Iptase antibodyAnti-Cis-Prenyltransferase Subunit Hcit antibodyAnti-Epididymis Tissue Protein Li 189m antibodyAnti-DHDDS antibodyAnti-HDS antibody |
Information sourced from Uniprot.org
