Anti-DGAT2 antibody (Internal) (STJ71113)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-DGAT2 (Internal) is suitable for use in ELISA, Immunohistochemistry and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IHC/FC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.IHC: In paraffin embedded Human Liver shows granular cytoplasm staining of hepatocytes. Recommended concentration: 3µg/ml.FC:Flow cytometric analysis of HeLa cells. Recommended conce |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DGAT2 |
| Gene ID | 84649 |
| Uniprot ID | DGAT2_HUMAN |
| Accession Number | NP_115953.2; NP_001240820.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | KLEHPTQQDIDLYH |
| Specificity | This antibody is not expected to cross-react with other DGAT members. |
Additional Info
| Function | Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG). |
| Protein Name | Diacylglycerol O-Acyltransferase 2Acyl-Coa Retinol O-Fatty-AcyltransferaseAratRetinol O-Fatty-AcyltransferaseDiglyceride Acyltransferase 2 |
| Database Links | Reactome: R-HSA-1482883Reactome: R-HSA-75109 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLipid DropletCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Diacylglycerol O-Acyltransferase 2 antibodyAnti-Acyl-Coa Retinol O-Fatty-Acyltransferase antibodyAnti-Arat antibodyAnti-Retinol O-Fatty-Acyltransferase antibodyAnti-Diglyceride Acyltransferase 2 antibodyAnti-DGAT2 antibodyAnti-HMFN1045 antibodyAnti-UNQ738 antibodyAnti-PRO1433 antibody |
Information sourced from Uniprot.org