| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DGAT2 |
| Gene ID: | 84649 |
| Uniprot ID: | DGAT2_HUMAN |
| Immunogen Region: | 289-388 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-388 of human DGAT2 (NP_115953.2). |
| Immunogen Sequence: | IFEEGSWGRWVQKKFQKYIG FAPCIFHGRGLFSSDTWGLV PYSKPITTVVGEPITIPKLE HPTQQDIDLYHTMYMEALVK LFDKHKTKFGLPETEVLEVN |
| Tissue Specificity | Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. |
| Function | Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG). |
| Protein Name | Diacylglycerol O-Acyltransferase 2 Acyl-Coa Retinol O-Fatty-Acyltransferase Arat Retinol O-Fatty-Acyltransferase Diglyceride Acyltransferase 2 |
| Database Links | Reactome: R-HSA-1482883 Reactome: R-HSA-75109 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Lipid Droplet Cytoplasm Perinuclear Region |
| Alternative Antibody Names | Anti-Diacylglycerol O-Acyltransferase 2 antibody Anti-Acyl-Coa Retinol O-Fatty-Acyltransferase antibody Anti-Arat antibody Anti-Retinol O-Fatty-Acyltransferase antibody Anti-Diglyceride Acyltransferase 2 antibody Anti-DGAT2 antibody Anti-HMFN1045 antibody Anti-UNQ738 antibody Anti-PRO1433 antibody |
Information sourced from Uniprot.org