Anti-Desmoplakin antibody (1672-1684) (STJ72283)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Desmoplakin (1672-1684) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments in lysates of cell lines HEK293, HeLa and NIH3T3 gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any fee |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DSP |
| Gene ID | 1832 |
| Uniprot ID | DESP_HUMAN |
| Accession Number | NP_004406.2 |
| Immunogen Region | 1672-1684 |
| Immunogen Sequence | QESVKQAHLRNEH |
| Specificity | This antibody is expected to recognize reported isoform I (NP_004406.2) only. |
Additional Info
| Function | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance. |
| Protein Name | DesmoplakinDp250/210 Kda Paraneoplastic Pemphigus Antigen |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell JunctionDesmosomeCell MembraneCytoplasmLocalizes To Desmosome Precursor Particles In The CytoplasmLocalizes To The Cytoplasm In Undifferentiated Keratinocytes However Becomes Localizes To Both Lateral And Tricellular Cell-Cell Contacts As Differentiation Progresses And As Epithelial Sheet Formation Completes |
| Alternative Antibody Names | Anti-Desmoplakin antibodyAnti-Dp antibodyAnti-250/210 Kda Paraneoplastic Pemphigus Antigen antibodyAnti-DSP antibody |
Information sourced from Uniprot.org