| Tissue Specificity | Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level). Also expressed in the buccal mucosa, esophagus and cervix (at protein level). |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function. Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage. Essential for successful completion of embryo compaction and embryo development. |
| Protein Name | Desmocollin-3Cadherin Family Member 3Desmocollin-4Ht-Cp |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeCytoplasmExpressed In The Cytoplasm And At The Cell Membrane Of Oocytes |
| Alternative Antibody Names | Anti-Desmocollin-3 antibodyAnti-Cadherin Family Member 3 antibodyAnti-Desmocollin-4 antibodyAnti-Ht-Cp antibodyAnti-DSC3 antibodyAnti-CDHF3 antibodyAnti-DSC4 antibody |
Information sourced from Uniprot.org
