Anti-DENR antibody (1-198) (STJ115654)

SKU:
STJ115654
£112.50 - £524.50
Free Shipping
Processing The item has been added

Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DENR
Gene ID: 8562
Uniprot ID: DENR_HUMAN
Immunogen Region: 1-198
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DENR (NP_003668.2).
Immunogen Sequence: MAADISESSGADCKGDPRNS AKLDADYPLRVLYCGVCSLP TEYCEYMPDVAKCRQWLEKN FPNEFAKLTVENSPKQEAGI SEGQGTAGEEEEKKKQKRGG RGQIKQKKKTVPQKVTIAKI PRAKKKYVTRVCGLATFEID LKEAQRFFAQKFSCGASVTG EDEIIIQGDFTDDIIDVIQE KWPEVDDDSIEDLGEVKK
Tissue Specificity Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
Function Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent.
Protein Name Density-Regulated Protein
Drp
Protein Drp1
Smooth Muscle Cell-Associated Protein 3
Smap-3
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Density-Regulated Protein antibody
Anti-Drp antibody
Anti-Protein Drp1 antibody
Anti-Smooth Muscle Cell-Associated Protein 3 antibody
Anti-Smap-3 antibody
Anti-DENR antibody
Anti-DRP1 antibody
Anti-H14 antibody

Information sourced from Uniprot.org