| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DENN domain-containing protein 2B (411-460 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DENND2B |
| Gene ID: |
6764 |
| Uniprot ID: |
DEN2B_HUMAN |
| Immunogen Region: |
411-460 aa |
| Specificity: |
ST5 Polyclonal Antibody detects endogenous levels of ST5 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ST5 at the amino acid range 411-460 |
| Post Translational Modifications | Phosphorylated. Phosphorylation decreases ITSN1 binding. |
| Function | Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Isoform 3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). |
| Protein Name | Denn Domain-Containing Protein 2bHela Tumor Suppression 1Suppression Of Tumorigenicity 5 Protein |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Isoform 1: CytoplasmCell CortexCell MembraneRecycling EndosomeColocalizes With Rab13 And Itsn1 At Cytoplasmic Vesicles That Are Most Likely Recycling EndosomesColocalizes With The Cortical Actin Cytoskeleton |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 2b antibodyAnti-Hela Tumor Suppression 1 antibodyAnti-Suppression Of Tumorigenicity 5 Protein antibodyAnti-DENND2B antibodyAnti-HTS1 antibodyAnti-ST5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
