| Post Translational Modifications | Phosphorylated. Phosphorylation decreases ITSN1 binding. |
| Function | Isoform 1: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane. Isoform 2: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Isoform 3: May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable). |
| Protein Name | Denn Domain-Containing Protein 2bHela Tumor Suppression 1Suppression Of Tumorigenicity 5 Protein |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Isoform 1: CytoplasmCell CortexCell MembraneRecycling EndosomeColocalizes With Rab13 And Itsn1 At Cytoplasmic Vesicles That Are Most Likely Recycling EndosomesColocalizes With The Cortical Actin Cytoskeleton |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 2b antibodyAnti-Hela Tumor Suppression 1 antibodyAnti-Suppression Of Tumorigenicity 5 Protein antibodyAnti-DENND2B antibodyAnti-HTS1 antibodyAnti-ST5 antibody |
Information sourced from Uniprot.org
