| Post Translational Modifications | Phosphorylated on serine and/or threonine in an Akt-dependent manner. Phosphorylation probably regulates the guanine nucleotide exchange factor (GEF) activity, possibly by disrupting an intramolecular interaction between the DENN domain and the C-terminus of the protein, thereby relieving the autoinhibition. |
| Function | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P. |
| Protein Name | Denn Domain-Containing Protein 1aConnecdenn 1ConnecdennProtein Fam31a |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinPresynaptic Cell MembraneAssociates To Membranes Via Lipid-Binding Activity |
| Alternative Antibody Names | Anti-Denn Domain-Containing Protein 1a antibodyAnti-Connecdenn 1 antibodyAnti-Connecdenn antibodyAnti-Protein Fam31a antibodyAnti-DENND1A antibodyAnti-FAM31A antibodyAnti-KIAA1608 antibody |
Information sourced from Uniprot.org
