Anti-DELE1 antibody (STJA0008739)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DELE1
Gene ID:	9812
Uniprot ID:	DELE1_HUMAN
Specificity:	This antibody detects endogenous levels of DELE1 at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human DELE1

Post Translational Modifications	DAP3-binding cell death enhancer 1: Unstable protein in absence of stress: imported in the mitochondrial matrix following processing by the mitochondrial-processing peptidase (MPP), where it is degraded by LONP1. Stabilized in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization. Cleaved by OMA1 in response to mitochondrial stress, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) that accumulates in the cytosol and activates the protein kinase activity of EIF2AK1/HRI. Protein cleavage by OMA1 can take place at different positions, and apparently does not require a specific sequence motif.
Function	Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. DAP3-binding cell death enhancer 1: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. DAP3-binding cell death enhancer 1 short form: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI. It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR.
Protein Name	Dap3-Binding Cell Death Enhancer 1 Dap3-Binding Cell Death Enhancer 1 - Long Form Dele1(L Death Ligand Signal Enhancer Cleaved Into - Dap3-Binding Cell Death Enhancer 1 Short Form Dele1(S S-Dele1
Cellular Localisation	Dap3-Binding Cell Death Enhancer 1: Mitochondrion Mitochondrion Outer Membrane Mitochondrion Inner Membrane Imported In The Mitochondrial Matrix In Absence Of Stress Leading To Its Degradation By Lonp1 Localizes At The Mitochondrial Surface In Response To Iron Deficiency: Iron Deficiency Impairs Mitochondrial Import Promoting Localization At The Mitochondrial Surface And Stabilization Associates With The Mitochondrion Inner Membrane In Response To Mitochondrial Stress Leading To Its Proteolytic Processing By Oma1 And Generation Of The Ap3-Binding Cell Death Enhancer 1 Short Form (Dele1(S) Or S-Dele1) Dap3-Binding Cell Death Enhancer 1 Short Form: Cytoplasm Cytosol This Short Form Is Generated By Proteolytic Processing By Oma1 In Response To Mitochondrial Stress Leading To Translocation To The Cytosol
Alternative Antibody Names	Anti-Dap3-Binding Cell Death Enhancer 1 antibody Anti-Dap3-Binding Cell Death Enhancer 1 - Long Form antibody Anti-Dele1(L antibody Anti-Death Ligand Signal Enhancer Cleaved Into - Dap3-Binding Cell Death Enhancer 1 Short Form antibody Anti-Dele1(S antibody Anti-S-Dele1 antibody Anti-DELE1 antibody Anti-DELE antibody Anti-KIAA0141 antibody

Information sourced from Uniprot.org

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