Anti-DEFB1 antibody (1-68 aa) (STJ11106331)

SKU:
STJ11106331
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: DEFB1
Gene ID: 1672
Uniprot ID: DEFB1_HUMAN
Immunogen Region: 1-68 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human DEFB1 (NP_005209.1).
Immunogen Sequence: MRTSYLLLFTLCLLLSEMAS GGNFLTGLGHRSDHYNCVSS GGQCLYSACPIFTKIQGTCY RGKAKCCK
Tissue Specificity Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Function Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
Protein Name Beta-Defensin 1
Bd-1
Hbd-1
Defensin - Beta 1
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Membrane
Associates With Tumor Cell Membrane-Derived Microvesicles
Alternative Antibody Names Anti-Beta-Defensin 1 antibody
Anti-Bd-1 antibody
Anti-Hbd-1 antibody
Anti-Defensin - Beta 1 antibody
Anti-DEFB1 antibody
Anti-BD1 antibody
Anti-HBD1 antibody

Information sourced from Uniprot.org

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