| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEFA1 (1-94) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEFA1.DEFA1B |
| Gene ID: |
1667/728358 |
| Uniprot ID: |
DEF1_HUMAN |
| Immunogen Region: |
1-94 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-94 of human DEFA1 (NP_004075.1). |
| Immunogen Sequence: |
MRTLAILAAILLVALQAQAE PLQARADEVAAAPEQIAADI PEVVVSLAWDESLAPKHPGS RKNMACYCRIPACIAGERRY GTCIYQGRLWAFCC |
| Post Translational Modifications | ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation. |
| Function | Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs. Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis. Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry. In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release. Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs. |
| Protein Name | Neutrophil Defensin 1Defensin - Alpha 1Hnp-1Hp-1Hp1 Cleaved Into - Hp 1-56 - Neutrophil Defensin 2Hnp-2Hp-2Hp2 |
| Database Links | Reactome: R-HSA-1461973Reactome: R-HSA-1462054Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neutrophil Defensin 1 antibodyAnti-Defensin - Alpha 1 antibodyAnti-Hnp-1 antibodyAnti-Hp-1 antibodyAnti-Hp1 Cleaved Into - Hp 1-56 - Neutrophil Defensin 2 antibodyAnti-Hnp-2 antibodyAnti-Hp-2 antibodyAnti-Hp2 antibodyAnti-DEFA1 antibodyAnti-DEF1 antibodyAnti-DEFA2 antibodyAnti-MRS.DEFA1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
