| Host: |
Rabbit |
| Applications: |
IF/ICC/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CLEC7A |
| Gene ID: |
64581 |
| Uniprot ID: |
CLC7A_HUMAN |
| Immunogen Region: |
66-247 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 66-247 of human Dectin-1 (NP_922938.1). |
| Immunogen Sequence: |
TMAIWRSNSGSNTLENGYFL SRNKENHSQPTQSSLEDSVT PTKAVKTTGVLSSPCPPNWI IYEKSCYLFSMSLNSWDGSK RQCWQLGSNLLKIDSSNELG FIVKQVSSQPDNSFWIGLSR PQTEVPWLWEDGSTFSSNLF QIRTTATQENPSPNCVWIHV SVIYDQLCSVPSYSICEKKF SM |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Database Links | Reactome: R-HSA-5607764 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform 5: CytoplasmIsoform 6: CytoplasmIsoform 7: Cytoplasm |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 7 Member A antibodyAnti-Beta-Glucan Receptor antibodyAnti-C-Type Lectin Superfamily Member 12 antibodyAnti-Dendritic Cell-Associated C-Type Lectin 1 antibodyAnti-Dc-Associated C-Type Lectin 1 antibodyAnti-Dectin-1 antibodyAnti-Cd Antigen Cd369 antibodyAnti-CLEC7A antibodyAnti-BGR antibodyAnti-CLECSF12 antibodyAnti-DECTIN1 antibodyAnti-UNQ539 antibodyAnti-PRO1082 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
